[HTML][HTML] Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia
O Blau, WK Hofmann, CD Baldus, G Thiel… - Experimental …, 2007 - Elsevier
OBJECTIVE: Bone marrow mesenchymal stroma cells (BMSC) are key components of the
hematopoietic microenvironment. The question of whether BMSC from patients with
hematological disorders have cytogenetic abnormalities is discussed controversially, some
studies indicating that they are cytogenetically normal and others providing evidence of their
aberrations. PATIENTS AND METHODS: We performed standard and molecular cytogenetic
analyses of both hematopoietic cells and BMSC from 31 patients with myelodysplastic …
hematopoietic microenvironment. The question of whether BMSC from patients with
hematological disorders have cytogenetic abnormalities is discussed controversially, some
studies indicating that they are cytogenetically normal and others providing evidence of their
aberrations. PATIENTS AND METHODS: We performed standard and molecular cytogenetic
analyses of both hematopoietic cells and BMSC from 31 patients with myelodysplastic …