The emerging role of ABL kinases in solid tumors
J Wang, AM Pendergast - Trends in cancer, 2015 - cell.com
J Wang, AM Pendergast
Trends in cancer, 2015•cell.comThe Abelson (ABL) tyrosine kinases have been identified as drivers of leukemia in mice and
humans. Emerging data demonstrate a role for the ABL family kinases, ABL1 and ABL2, in
the progression of several solid tumors. This review focuses on recent reports of the
involvement of the ABL kinases in tumor progression using mouse models, as well as on
recent data generated from genomic and proteomic studies linking enhanced expression
and hyperactivation of the ABL kinases to human cancers. Preclinical studies on small …
humans. Emerging data demonstrate a role for the ABL family kinases, ABL1 and ABL2, in
the progression of several solid tumors. This review focuses on recent reports of the
involvement of the ABL kinases in tumor progression using mouse models, as well as on
recent data generated from genomic and proteomic studies linking enhanced expression
and hyperactivation of the ABL kinases to human cancers. Preclinical studies on small …
The Abelson (ABL) tyrosine kinases have been identified as drivers of leukemia in mice and humans. Emerging data demonstrate a role for the ABL family kinases, ABL1 and ABL2, in the progression of several solid tumors. This review focuses on recent reports of the involvement of the ABL kinases in tumor progression using mouse models, as well as on recent data generated from genomic and proteomic studies linking enhanced expression and hyperactivation of the ABL kinases to human cancers. Preclinical studies on small-molecule inhibitors of the ABL kinases suggest that their use may be of benefit in the treatment of selected solid tumors.
cell.com