Alpha1-Antitrypsin Deficiency
EK Silverman, RA Sandhaus - New England Journal of Medicine, 2009 - Mass Medical Soc
EK Silverman, RA Sandhaus
New England Journal of Medicine, 2009•Mass Medical SocA 60-year-old white man presents for evaluation of progressive dyspnea. He is a former
smoker with a 20-pack-year smoking history and a 10-year history of chronic obstructive
pulmonary disease (COPD). There is no family history of COPD. Severe airflow obstruction
is seen on spirometry, with a forced expiratory volume in 1 second that is 40% of the
predicted value. Should he be evaluated for alpha1-antitrypsin (AAT) deficiency? If AAT
deficiency is documented, how should his case be managed?
smoker with a 20-pack-year smoking history and a 10-year history of chronic obstructive
pulmonary disease (COPD). There is no family history of COPD. Severe airflow obstruction
is seen on spirometry, with a forced expiratory volume in 1 second that is 40% of the
predicted value. Should he be evaluated for alpha1-antitrypsin (AAT) deficiency? If AAT
deficiency is documented, how should his case be managed?
A 60-year-old white man presents for evaluation of progressive dyspnea. He is a former smoker with a 20-pack-year smoking history and a 10-year history of chronic obstructive pulmonary disease (COPD). There is no family history of COPD. Severe airflow obstruction is seen on spirometry, with a forced expiratory volume in 1 second that is 40% of the predicted value. Should he be evaluated for alpha1-antitrypsin (AAT) deficiency? If AAT deficiency is documented, how should his case be managed?
The New England Journal Of Medicine