Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T-and B cell-independent, but is associated with …
HJ McSorley, NF Blair, E Robertson… - Experimental …, 2015 - Elsevier
The murine intestinal nematode Heligmosomoides polygyrus exerts multiple
immunomodulatory effects in the host, including the suppression of allergic inflammation in
mice sensitized to allergen presented with alum adjuvant. Similar suppression is attained by
co-administration of H. polygyrus excretory/secretory products (HES) with the sensitizing
dose of ovalbumin (OVA) in alum. We investigated the mechanism of suppression by HES in
this model, and found it was maintained in MyD88xTRIF-deficient mice, implying no role for …
immunomodulatory effects in the host, including the suppression of allergic inflammation in
mice sensitized to allergen presented with alum adjuvant. Similar suppression is attained by
co-administration of H. polygyrus excretory/secretory products (HES) with the sensitizing
dose of ovalbumin (OVA) in alum. We investigated the mechanism of suppression by HES in
this model, and found it was maintained in MyD88xTRIF-deficient mice, implying no role for …
