[HTML][HTML] LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells
The activation of LFA-1 (lymphocyte function-associated antigen) is a critical event for T cell
co-stimulation. The mechanism of LFA-1 activation involves both affinity and avidity
regulation, but the role of each in T cell activation remains unclear. We have identified
antibodies that recognize and block different affinity states of the mouse LFA-1 I-domain.
Monoclonal antibody 2D7 preferentially binds to the low affinity conformation, and this
specific binding is abolished when LFA-1 is locked in the high affinity conformation. In …
co-stimulation. The mechanism of LFA-1 activation involves both affinity and avidity
regulation, but the role of each in T cell activation remains unclear. We have identified
antibodies that recognize and block different affinity states of the mouse LFA-1 I-domain.
Monoclonal antibody 2D7 preferentially binds to the low affinity conformation, and this
specific binding is abolished when LFA-1 is locked in the high affinity conformation. In …