Liver transplantation has emerged as a vital therapy for end-stage liver diseases. Acute−
phase inflammation play an important role in liver graft injury. Recent studies have revealed
that inflammasome are responsible for initiating inflammation in early stage of acute organ
rejection in liver transplantation, however the underlying mechanism remains unclear. Here
we explored to block inflammasome activation to see whether it can alleviate early
inflammation reaction during rejection of allgrafts in a rat model and gain further insights into …