[HTML][HTML] Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies

J Reeve, J Sellarés, M Mengel, B Sis, A Skene… - American Journal of …, 2013 - Elsevier
Histologic diagnosis of T cell-mediated rejection is flawed by subjective assessments,
nonspecific lesions and arbitrary rules. This study developed a molecular test for T cell-
mediated rejection. We used microarray results from 403 kidney transplant biopsies to
derive a classifier assigning T cell-mediated rejection scores to all biopsies, and compared
these with histologic assessments. The score correlated with histologic lesions of T cell-
mediated rejection (infiltrate, tubulitis). The accuracy of the classifier for the histology …