[HTML][HTML] Oxygen sensors at the crossroad of metabolism

J Aragonés, P Fraisl, M Baes, P Carmeliet - Cell metabolism, 2009 - cell.com
J Aragonés, P Fraisl, M Baes, P Carmeliet
Cell metabolism, 2009cell.com
Aerobic organisms developed mechanisms to protect themselves against a shortage of
oxygen (O 2). Recent studies reveal that O 2 sensors, belonging to the novel class of 2-
oxoglutarate dependent iron (ii)-dioxygenases, have more important roles in metabolism
than anticipated. Here, we provide a" metabolo-centric" overview of the role of the PHD/FIH
members of this family in metabolism, in particular on how they regulate O 2 supply and
consumption, energy compensation and conservation, O 2 conformance and hypoxia …
Aerobic organisms developed mechanisms to protect themselves against a shortage of oxygen (O2). Recent studies reveal that O2 sensors, belonging to the novel class of 2-oxoglutarate dependent iron(ii)-dioxygenases, have more important roles in metabolism than anticipated. Here, we provide a "metabolo-centric" overview of the role of the PHD/FIH members of this family in metabolism, in particular on how they regulate O2 supply and consumption, energy compensation and conservation, O2 conformance and hypoxia tolerance, redox and pH homeostasis, and other vital metabolic processes with implications in health and disease. These insights may offer novel opportunities for the treatment of ischemic diseases.
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