[PDF][PDF] Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity

Y Cao - Cell metabolism, 2013 - cell.com
Cell metabolism, 2013cell.com
White and brown adipose tissues are hypervascularized and the adipose vasculature
displays phenotypic and functional plasticity to coordinate with metabolic demands of
adipocytes. Blood vessels not only supply nutrients and oxygen to nourish adipocytes, they
also serve as a cellular reservoir to provide adipose precursor and stem cells that control
adipose tissue mass and function. Multiple signaling molecules modulate the complex
interplay between the vascular system and the adipocytes. Understanding fundamental …
White and brown adipose tissues are hypervascularized and the adipose vasculature displays phenotypic and functional plasticity to coordinate with metabolic demands of adipocytes. Blood vessels not only supply nutrients and oxygen to nourish adipocytes, they also serve as a cellular reservoir to provide adipose precursor and stem cells that control adipose tissue mass and function. Multiple signaling molecules modulate the complex interplay between the vascular system and the adipocytes. Understanding fundamental mechanisms by which angiogenesis and vasculatures modulate adipocyte functions may provide new therapeutic options for treatment of obesity and metabolic disorders by targeting the adipose vasculature.
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