Adenosine regulates tissue factor expression on endothelial cells
H Deguchi, H Takeya, H Urano, EC Gabazza… - Thrombosis research, 1998 - Elsevier
The aim of this study was to evaluate the inhibitory activity of adenosine on tumor necrosis
factor-α (TNF), thrombin-, or phorbol 12-myristate 13-acetate (PMA)-induced tissue factor
(TF) expression on human umbilical vein endothelial cells (HUVECs). This inhibitory effect of
adenosine was found to be counteracted by the non-selective adenosine receptor (AR)
antagonist, 8-(p-sulfophenyl) theophylline. To clarify the role of ARs (A1, A2a, A2b, and A3)
in this regulation, we evaluated the effect of several agonists and antagonists specific for AR …
factor-α (TNF), thrombin-, or phorbol 12-myristate 13-acetate (PMA)-induced tissue factor
(TF) expression on human umbilical vein endothelial cells (HUVECs). This inhibitory effect of
adenosine was found to be counteracted by the non-selective adenosine receptor (AR)
antagonist, 8-(p-sulfophenyl) theophylline. To clarify the role of ARs (A1, A2a, A2b, and A3)
in this regulation, we evaluated the effect of several agonists and antagonists specific for AR …