[HTML][HTML] Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in …
IL-6 has been shown to play a major role in collagen up-regulation process during cardiac
hypertrophy, although the precise mechanism is still not known. In this study we have
analyzed the mechanism by which IL-6 modulates cardiac hypertrophy. For the in vitro
model, IL-6-treated cultured cardiac fibroblasts were used, whereas the in vivo cardiac
hypertrophy model was generated by renal artery ligation in adult male Wistar rats (Rattus
norvegicus). During induction of hypertrophy, increased phosphorylation of STAT1, STAT3 …
hypertrophy, although the precise mechanism is still not known. In this study we have
analyzed the mechanism by which IL-6 modulates cardiac hypertrophy. For the in vitro
model, IL-6-treated cultured cardiac fibroblasts were used, whereas the in vivo cardiac
hypertrophy model was generated by renal artery ligation in adult male Wistar rats (Rattus
norvegicus). During induction of hypertrophy, increased phosphorylation of STAT1, STAT3 …