Macrolide antibiotics promote the LPS-induced upregulation of prostaglandin E receptor EP2 and thus attenuate macrolide suppression of IL-6 production
Y Sato, K Kaneko, M Inoue - Prostaglandins, leukotrienes and essential …, 2007 - Elsevier
We studied the influence of the inhibitory effect of clarithromycin (CAM) and erythromycin
(EM) on the production of macrophage inflammatory protein (MIP)-2, interleukin-6 (IL-6), and
prostaglandin E2 (PGE2), as well as PGE2 receptor (EP2) expression, by LPS-stimulated
RAW264. 7 cells. Production of IL-6 was significantly decreased by treatment with CAM or
EM in a dose-dependent manner, but the inhibitory effect of CAM was significantly weaker
than that of EM. In contrast, the production of MIP-2 and PGE2 was inhibited to the same …
(EM) on the production of macrophage inflammatory protein (MIP)-2, interleukin-6 (IL-6), and
prostaglandin E2 (PGE2), as well as PGE2 receptor (EP2) expression, by LPS-stimulated
RAW264. 7 cells. Production of IL-6 was significantly decreased by treatment with CAM or
EM in a dose-dependent manner, but the inhibitory effect of CAM was significantly weaker
than that of EM. In contrast, the production of MIP-2 and PGE2 was inhibited to the same …
