ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles
Background & Aims Excessive alcohol consumption is one of the major causes of
hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are
deficient for aldehyde dehydrogenase 2 (ALDH2), a key enzyme that detoxifies the ethanol
metabolite acetaldehyde. However, how ALDH2 deficiency affects alcohol-related HCC
remains unclear. Methods ALDH2 polymorphisms were studied in 646 patients with viral
hepatitis B (HBV) infection, who did or did not drink alcohol. A new model of HCC induced …
hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are
deficient for aldehyde dehydrogenase 2 (ALDH2), a key enzyme that detoxifies the ethanol
metabolite acetaldehyde. However, how ALDH2 deficiency affects alcohol-related HCC
remains unclear. Methods ALDH2 polymorphisms were studied in 646 patients with viral
hepatitis B (HBV) infection, who did or did not drink alcohol. A new model of HCC induced …