[HTML][HTML] Activation of mitogen-activated protein kinase by h2o2: role in cell survival following oxidant injury (∗)
The mitogen-activated protein kinase (MAPK) family is comprised of key regulatory proteins
that control the cellular response to both proliferation and stress signals. In this study we
investigated the factors controlling MAPK activation by H 2 O 2 and explored the impact of
altering the pathways to kinase activation on cell survival following H 2 O 2 exposure. Potent
activation (10-20-fold) of extracellular signal-regulated protein kinase (ERK2) occurred
within 10 min of H 2 O 2 treatment, whereupon rapid inactivation ensued. H 2 O 2 activated …
that control the cellular response to both proliferation and stress signals. In this study we
investigated the factors controlling MAPK activation by H 2 O 2 and explored the impact of
altering the pathways to kinase activation on cell survival following H 2 O 2 exposure. Potent
activation (10-20-fold) of extracellular signal-regulated protein kinase (ERK2) occurred
within 10 min of H 2 O 2 treatment, whereupon rapid inactivation ensued. H 2 O 2 activated …