[HTML][HTML] Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary …
CD9 and CD81 are closely related tetraspanins that regulate cell motility and signaling by
facilitating the organization of multimolecular membrane complexes, including integrins. We
show that CD9 and CD81 are down-regulated in smoking-related inflammatory response of
a macrophage line, RAW264. 7. When functions of CD9 and CD81 were ablated with
monoclonal antibody treatment, small interfering RNA transfection, or gene knock-out,
macrophages were less motile and produced larger amounts of matrix metalloproteinase …
facilitating the organization of multimolecular membrane complexes, including integrins. We
show that CD9 and CD81 are down-regulated in smoking-related inflammatory response of
a macrophage line, RAW264. 7. When functions of CD9 and CD81 were ablated with
monoclonal antibody treatment, small interfering RNA transfection, or gene knock-out,
macrophages were less motile and produced larger amounts of matrix metalloproteinase …