[HTML][HTML] FPRP, a major, highly stoichiometric, highly specific CD81-and CD9-associated protein
CD81 and CD9, members of the transmembrane-4 superfamily (TM4SF; tetraspanins), form
extensive complexes with other TM4SF proteins, integrins, and other proteins, especially in
mild detergents. In moderately stringent Brij 96 lysis conditions, CD81 and CD9 complexes
are virtually identical to each other, but clearly distinct from other TM4SF complexes. One of
the most prominent proteins within CD81 and CD9 complexes is identified here as FPRP,
the 133-kDa prostaglandin F 2α receptor regulatory protein. FPRP, a cell-surface Ig …
extensive complexes with other TM4SF proteins, integrins, and other proteins, especially in
mild detergents. In moderately stringent Brij 96 lysis conditions, CD81 and CD9 complexes
are virtually identical to each other, but clearly distinct from other TM4SF complexes. One of
the most prominent proteins within CD81 and CD9 complexes is identified here as FPRP,
the 133-kDa prostaglandin F 2α receptor regulatory protein. FPRP, a cell-surface Ig …