The pathogenesis of acute kidney impairment in patients with multiple myeloma
V Batuman - Advances in chronic kidney disease, 2012 - Elsevier
Acute kidney injury in myeloma, a serious complication associated with poor prognosis, is
generally mediated by the toxic and inflammatory effects of monoclonal free light chains
(FLCs) on kidney proximal tubule cells and by the formation of intratubular casts through
interaction with Tamm-Horsfall proteins. Production of excessive quantities of FLCs is seen
in most cases of FLC-associated kidney injury, although a direct relation between quantity
and nephrotoxicity does not exist, indicating variable toxicity among light chain species …
generally mediated by the toxic and inflammatory effects of monoclonal free light chains
(FLCs) on kidney proximal tubule cells and by the formation of intratubular casts through
interaction with Tamm-Horsfall proteins. Production of excessive quantities of FLCs is seen
in most cases of FLC-associated kidney injury, although a direct relation between quantity
and nephrotoxicity does not exist, indicating variable toxicity among light chain species …