Induction of immunological tolerance by porcine liver allografts
RY Calne, RA Sells, JR Pena, DR Davis, PR Millard… - Nature, 1969 - nature.com
RY Calne, RA Sells, JR Pena, DR Davis, PR Millard, BM Herbertson, RM Binns, DAL Davies
Nature, 1969•nature.comLiver allografting experiments with pigs show that animals given no immunosuppression will
survive for prolonged periods with orthotopic liver transplants. Similar animals can reject
skin, kidneys and hearts rapidly. Orthotopic and accessory heterotopic liver allografts protect
preferentially from rejection grafts of donor specific skin, kidney and possibly heart. Injected
soluble liver antigen may also protect donor specific tissue from rejection. It is suggested that
allogeneic liver can induce immunological tolerance in immunologically mature pigs.
survive for prolonged periods with orthotopic liver transplants. Similar animals can reject
skin, kidneys and hearts rapidly. Orthotopic and accessory heterotopic liver allografts protect
preferentially from rejection grafts of donor specific skin, kidney and possibly heart. Injected
soluble liver antigen may also protect donor specific tissue from rejection. It is suggested that
allogeneic liver can induce immunological tolerance in immunologically mature pigs.
Abstract
Liver allografting experiments with pigs show that animals given no immunosuppression will survive for prolonged periods with orthotopic liver transplants. Similar animals can reject skin, kidneys and hearts rapidly. Orthotopic and accessory heterotopic liver allografts protect preferentially from rejection grafts of donor specific skin, kidney and possibly heart. Injected soluble liver antigen may also protect donor specific tissue from rejection. It is suggested that allogeneic liver can induce immunological tolerance in immunologically mature pigs.
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