Immune escape mechanisms as a guide for cancer immunotherapy
GL Beatty, WL Gladney - Clinical cancer research, 2015 - AACR
GL Beatty, WL Gladney
Clinical cancer research, 2015•AACRImmunotherapy has demonstrated impressive outcomes for some patients with cancer.
However, selecting patients who are most likely to respond to immunotherapy remains a
clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and
present strategies for applying this knowledge to improving the efficacy of cancer
immunotherapy. Clin Cancer Res; 21 (4); 687–92.© 2014 AACR.
However, selecting patients who are most likely to respond to immunotherapy remains a
clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and
present strategies for applying this knowledge to improving the efficacy of cancer
immunotherapy. Clin Cancer Res; 21 (4); 687–92.© 2014 AACR.
Abstract
Immunotherapy has demonstrated impressive outcomes for some patients with cancer. However, selecting patients who are most likely to respond to immunotherapy remains a clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and present strategies for applying this knowledge to improving the efficacy of cancer immunotherapy. Clin Cancer Res; 21(4); 687–92. ©2014 AACR.
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