Cholecystokinin receptors: presence and axonal flow in the rat vagus nerve

MA Zarbin, JK Wamsley, RB Innis, MJ Kuhar - Life sciences, 1981 - Elsevier
MA Zarbin, JK Wamsley, RB Innis, MJ Kuhar
Life sciences, 1981Elsevier
Cholecystokinin (CCK) receptors have been detected in the rat vagus nerve. Ligation
experiments have revealed a time dependent build up of the receptors at the ligature which
is blocked by colchicine. Thus, at least a fraction of the receptors are being transported
peripherally, presumably by fast flow. The possible involvement of these vagal CCK
receptors with the ability of CCK to induce satiety is discussed.
Abstract
Cholecystokinin (CCK) receptors have been detected in the rat vagus nerve. Ligation experiments have revealed a time dependent build up of the receptors at the ligature which is blocked by colchicine. Thus, at least a fraction of the receptors are being transported peripherally, presumably by fast flow. The possible involvement of these vagal CCK receptors with the ability of CCK to induce satiety is discussed.
Elsevier