Maternal asthma and microRNA regulation of soluble HLA-G in the airway
J Nicodemus-Johnson, B Laxman, RK Stern… - Journal of Allergy and …, 2013 - Elsevier
BACKGROUND: We previously reported an interaction between maternal asthma and the
child's HLA-G genotype on the child's subsequent risk for asthma. The implicated single
nucleotide polymorphism at+ 3142 disrupted a target site for the microRNA (miR)-152 family.
We hypothesized that the interaction effect might be mediated by these miRs. OBJECTIVE:
The objective of this study was to test this hypothesis in adults with asthma who are a subset
of the same subjects who participated in our earlier family-based studies. METHODS: We …
child's HLA-G genotype on the child's subsequent risk for asthma. The implicated single
nucleotide polymorphism at+ 3142 disrupted a target site for the microRNA (miR)-152 family.
We hypothesized that the interaction effect might be mediated by these miRs. OBJECTIVE:
The objective of this study was to test this hypothesis in adults with asthma who are a subset
of the same subjects who participated in our earlier family-based studies. METHODS: We …