Differential expression of glycogenes in tonsillar B lymphocytes in association with proteinuria and renal dysfunction in IgA nephropathy

T Inoue, H Sugiyama, Y Hiki, K Takiue, H Morinaga… - Clinical …, 2010 - Elsevier
Aberrant O-glycosylation of serum and tonsillar IgA1 is one of the main pathogeneses of IgA
nephropathy (IgAN). However, the synthesis of underglycosylated IgA1 in tonsils has not yet
been characterized. This study examined tonsillar B lymphocytes of IgAN (n= 34) using
tonsils derived from patients with chronic tonsillitis (n= 24) and sleep apnea syndrome (n=
14) as a control. Gene expression of β1, 3-galactosyltransferase (β3GalT), and the core 1
β3GalT-specific molecular chaperone, Cosmc, UDP-N-acetyl-α-D-galactosamine …