[HTML][HTML] Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and …

A Yemelyanova, R Vang, M Kshirsagar, D Lu… - Modern pathology, 2011 - Elsevier
Immunohistochemical staining for p53 is used as a surrogate for mutational analysis in the
diagnostic workup of carcinomas of multiple sites including ovarian cancers. Strong and
diffuse immunoexpression of p53 is generally interpreted as likely indicating a TP53 gene
mutation. The immunoprofile that correlates with wild-type TP53, however, is not as clear. In
particular, the significance of completely negative immunostaining is controversial. The aim
of this study was to clarify the relationship of the immunohistochemical expression of p53 …