Mismatch repair protein expression in endometrioid intraepithelial neoplasia/atypical hyperplasia: should we screen for Lynch syndrome in precancerous lesions?
E Lucas, H Chen, K Molberg… - International Journal …, 2019 - journals.lww.com
Screening for Lynch syndrome (LS) is routinely performed in patients with endometrial
carcinoma. Currently, no screening recommendations exist for LS in precancerous lesions.
The study goal was to determine the incidence of abnormal protein expression in
endometrioid intraepithelial neoplasia/atypical hyperplasia (EIN/AH). We analyzed
mismatch repair (MMR) protein expression by immunohistochemistry in EIN/AH concurrent
with MMR-deficient endometrial carcinomas, and in endometrial biopsy/curettage …
carcinoma. Currently, no screening recommendations exist for LS in precancerous lesions.
The study goal was to determine the incidence of abnormal protein expression in
endometrioid intraepithelial neoplasia/atypical hyperplasia (EIN/AH). We analyzed
mismatch repair (MMR) protein expression by immunohistochemistry in EIN/AH concurrent
with MMR-deficient endometrial carcinomas, and in endometrial biopsy/curettage …