CD4CD8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques
CR Diedrich, HP Gideon, T Rutledge… - Journal of medical …, 2019 - Wiley Online Library
CR Diedrich, HP Gideon, T Rutledge, TM Baranowski, P Maiello, AJ Myers, PL Lin
Journal of medical primatology, 2019•Wiley Online LibraryBackground Tuberculosis (TB) kills millions of people every year. CD 4 and CD 8 T cells are
critical in the immune response against TB. T cells expressing both CD 4 and CD 8 (CD 4
CD 8 T cells) are functionally active and have not been examined in the context of TB.
Methods We examine peripheral blood mononuclear cells (PBMC) and bronchoalveolar
lavage cells (BAL) and lung granulomas from 28 cynomolgus macaques during
Mycobacterium tuberculosis (Mtb) infection. Results CD 4 CD 8 T cells increase in frequency …
critical in the immune response against TB. T cells expressing both CD 4 and CD 8 (CD 4
CD 8 T cells) are functionally active and have not been examined in the context of TB.
Methods We examine peripheral blood mononuclear cells (PBMC) and bronchoalveolar
lavage cells (BAL) and lung granulomas from 28 cynomolgus macaques during
Mycobacterium tuberculosis (Mtb) infection. Results CD 4 CD 8 T cells increase in frequency …
Background
Tuberculosis (TB) kills millions of people every year. CD4 and CD8 T cells are critical in the immune response against TB. T cells expressing both CD4 and CD8 (CD4CD8 T cells) are functionally active and have not been examined in the context of TB.
Methods
We examine peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage cells (BAL) and lung granulomas from 28 cynomolgus macaques during Mycobacterium tuberculosis (Mtb) infection.
Results
CD4CD8 T cells increase in frequency during early Mtb infection in PBMC and BAL from pre‐infection. Peripheral, airway, and lung granuloma CD4CD8 T cells have distinct patterns and greater cytokine production than CD4 or CD8 T cells.
Conclusion
Our data suggest that CD4CD8 T cells transient the blood and airways early during infection to reach the granulomas where they are involved directly in the host response to Mtb.
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