Differential T cell responses against DosR-associated antigen Rv2028c in BCG-vaccinated populations with tuberculosis infection
HM Zhao, R Du, CL Li, P Ji, H Li, K Wu, Z Hu, SH Lu… - Journal of Infection, 2019 - Elsevier
The IFN-γ release assays (IGRAs) based on region of difference 1 (RD1) antigens have
improved diagnosis of Mycobacterium tuberculosis (Mtb) infection. However, IGRAs with
these antigens could not distinguish latent tuberculosis infection (LTBI) from active
tuberculosis (ATB). DosR regulon genes are thought to be important for Mtb dormancy, and
their products have higher immunogenicity in LTBI than ATB individuals, suggesting
protective immunity mediated by DosR regulon-encoded antigens and potential utility of …
improved diagnosis of Mycobacterium tuberculosis (Mtb) infection. However, IGRAs with
these antigens could not distinguish latent tuberculosis infection (LTBI) from active
tuberculosis (ATB). DosR regulon genes are thought to be important for Mtb dormancy, and
their products have higher immunogenicity in LTBI than ATB individuals, suggesting
protective immunity mediated by DosR regulon-encoded antigens and potential utility of …
