The use of laboratory animals is critical to the discovery and in vivo pre-clinical testing of
new drugs and drug combinations for use in humans. M. tuberculosis infection of mice, rats,
guinea pigs, rabbits and non-human primates are the most commonly used animal models
of human tuberculosis. While granulomatous inflammation characterizes the most
fundamental host response to M. tuberculosis aerosol infection in humans and animals,
there are important species differences in pulmonary and extra-pulmonary lesion …