339 active myocardial regeneration resulting from transdifferentiation of the administered
stem cells. 4, 12–14 However, new data have led to the recognition of alternative
mechanisms of action (Figure 1): Exogenous stem cells may also stimulate proliferation of
endogenous cardiac precursors or stem cells through neovascularization6, 15 or paracrine
signaling actions. 16 In fact, observations in preclinical and clinical scenarios that all of
these events occur allow us to generate a new concept that cellular therapy contributes to …

Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair. Ready for the
Next Step Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair.
Ready for the Next Step Circulation. 2006 Jul 25;114(4):339-52. doi: 10.1161/CIRCULATIONAHA.105.590653.
Authors Andrew J Boyle 1 , Steven P Schulman, Joshua M Hare, Peter Oettgen Affiliation 1
Department of Medicine, Division of Cardiology, Institute for Cell Engineering, and Specialized
Center for Cell-Based Therapy, The Johns Hopkins University School of Medicine, Baltimore …