Abstract Effects of human activated protein C (APC) and heparin on thrombus formation
were examined using small mesenteric arteries of rats and video-recording system attached
to a microscope. To induce thrombosis we damaged the vessel wall over a short segment by
compression and exposed the damaged media to the blood stream. Platelet-rich thrombus
enlarged gradually at the damaged site, occluded the vascular lumen for a short period and
then flowed away. Such thrombus formation was observed several times after a …