[HTML][HTML] Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
M Sato, N Hata, M Asagiri, T Nakaya, T Taniguchi… - FEBS letters, 1998 - Elsevier
M Sato, N Hata, M Asagiri, T Nakaya, T Taniguchi, N Tanaka
FEBS letters, 1998•ElsevierThe interferon regulatory factor (IRF) family of transcription factors regulate the interferon
(IFN) system, among which IRF-3 is involved in the virus-induced IFN-β gene expression.
Here we show that another member IRF-7 is critical for the IFN-α gene induction. Unlike the
IRF-3 gene, the IRF-7 gene is induced by IFNs through activation of the ISGF3 transcription
factor, and IRF-7 undergoes virus-induced nuclear translocation. In cells lacking p48, an
essential component of IFN stimulated gene factor 3 (ISGF3), ectopic expression of IRF-7 but …
(IFN) system, among which IRF-3 is involved in the virus-induced IFN-β gene expression.
Here we show that another member IRF-7 is critical for the IFN-α gene induction. Unlike the
IRF-3 gene, the IRF-7 gene is induced by IFNs through activation of the ISGF3 transcription
factor, and IRF-7 undergoes virus-induced nuclear translocation. In cells lacking p48, an
essential component of IFN stimulated gene factor 3 (ISGF3), ectopic expression of IRF-7 but …
The interferon regulatory factor (IRF) family of transcription factors regulate the interferon (IFN) system, among which IRF-3 is involved in the virus-induced IFN-β gene expression. Here we show that another member IRF-7 is critical for the IFN-α gene induction. Unlike the IRF-3 gene, the IRF-7 gene is induced by IFNs through activation of the ISGF3 transcription factor, and IRF-7 undergoes virus-induced nuclear translocation. In cells lacking p48, an essential component of IFN stimulated gene factor 3 (ISGF3), ectopic expression of IRF-7 but not IRF-3 can rescue the deficiency to induce IFN-α genes. These results indicate that IRF-7 is a key factor in the positive feedback regulation of IFN-α/β production.
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