[HTML][HTML] Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages
Y Xu, F Toure, W Qu, L Lin, F Song, X Shen… - Journal of biological …, 2010 - ASBMB
Receptor for advanced glycation end product (RAGE)-dependent signaling has been
implicated in ischemia/reperfusion injury in the heart, lung, liver, and brain. Because
macrophages contribute to vascular perturbation and tissue injury in hypoxic settings, we
tested the hypothesis that RAGE regulates early growth response-1 (Egr-1) expression in
hypoxia-exposed macrophages. Molecular analysis, including silencing of RAGE, or
blockade of RAGE with sRAGE (the extracellular ligand-binding domain of RAGE), anti …
implicated in ischemia/reperfusion injury in the heart, lung, liver, and brain. Because
macrophages contribute to vascular perturbation and tissue injury in hypoxic settings, we
tested the hypothesis that RAGE regulates early growth response-1 (Egr-1) expression in
hypoxia-exposed macrophages. Molecular analysis, including silencing of RAGE, or
blockade of RAGE with sRAGE (the extracellular ligand-binding domain of RAGE), anti …