Phosphorylation of ribosomal protein S6 mediates mammalian target of rapamycin complex 1–induced parathyroid cell proliferation in secondary hyperparathyroidism

O Volovelsky, G Cohen, A Kenig… - Journal of the …, 2016 - journals.lww.com
Secondary hyperparathyroidism is characterized by increased serum parathyroid hormone
(PTH) level and parathyroid cell proliferation. However, the molecular pathways mediating
the increased parathyroid cell proliferation remain undefined. Here, we found that the mTOR
pathway was activated in the parathyroid of rats with secondary hyperparathyroidism
induced by either chronic hypocalcemia or uremia, which was measured by increased
phosphorylation of ribosomal protein S6 (rpS6), a downstream target of the mTOR pathway …