Mammalian target of rapamycin signaling is a mechanistic link between increased endoplasmic reticulum stress and autophagy in the placentas of pregnancies …
TH Hung, CP Wu, MJ Li, YL Yeh, SF Chen - Placenta, 2017 - Elsevier
Introduction Increased endoplasmic reticulum (ER) stress and autophagy have been noted
in the placentas of pregnancies complicated by idiopathic intrauterine growth restriction
(IUGR); however, the cause of these phenomena remains unclear. We surmised that oxygen-
glucose deprivation (OGD) may increase ER stress and autophagy and that mammalian
target of rapamycin (mTOR) signaling is involved in regulating placental ER stress and
autophagy in pregnancies complicated by IUGR. Methods We obtained placentas from …
in the placentas of pregnancies complicated by idiopathic intrauterine growth restriction
(IUGR); however, the cause of these phenomena remains unclear. We surmised that oxygen-
glucose deprivation (OGD) may increase ER stress and autophagy and that mammalian
target of rapamycin (mTOR) signaling is involved in regulating placental ER stress and
autophagy in pregnancies complicated by IUGR. Methods We obtained placentas from …
