Regulation of scleraxis function by interaction with the bHLH protein E47
AL Carlberg, RS Tuan, DJ Hall - Molecular Cell Biology Research …, 2000 - Elsevier
Scleraxis is a basic helix-loop-helix (bHLH) protein whose function has been postulated to
be preconfigurative of sclerotomal mesenchymal patterning during early embryonic
development by regulating expression of differentiation-specific genes, particularly those
involved in chondrogenesis. To gain understanding of the molecular action of scleraxis we
test the hypothesis that it heterodimerizes with another bHLH protein to activate gene
expression. Transient coexpression of scleraxis and E47, a candidate bHLH protein …
be preconfigurative of sclerotomal mesenchymal patterning during early embryonic
development by regulating expression of differentiation-specific genes, particularly those
involved in chondrogenesis. To gain understanding of the molecular action of scleraxis we
test the hypothesis that it heterodimerizes with another bHLH protein to activate gene
expression. Transient coexpression of scleraxis and E47, a candidate bHLH protein …
