A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats
A Bhatwadekar, JV Glenn, JL Figarola… - British journal of …, 2008 - bjo.bmj.com
A Bhatwadekar, JV Glenn, JL Figarola, S Scott, TA Gardiner, S Rahbar, AW Stitt
British journal of ophthalmology, 2008•bjo.bmj.comBackground: Diabetic retinopathy is associated with accumulation of advanced glycation
end products in the retinal microvasculature. LR-90 is an effective multistage inhibitor of
advanced glycation with renoprotective and anti-inflammatory properties. Aim: To explore
the role of LR-90 in the progression of experimental diabetic retinopathy. Methods:
Streptozotocin-induced diabetic Sprague–Dawley rats were treated with LR-90 (50 mg/l in
drinking water) for up to 32 weeks. At the end of the study, eyes were enucleated and …
end products in the retinal microvasculature. LR-90 is an effective multistage inhibitor of
advanced glycation with renoprotective and anti-inflammatory properties. Aim: To explore
the role of LR-90 in the progression of experimental diabetic retinopathy. Methods:
Streptozotocin-induced diabetic Sprague–Dawley rats were treated with LR-90 (50 mg/l in
drinking water) for up to 32 weeks. At the end of the study, eyes were enucleated and …
Background
Diabetic retinopathy is associated with accumulation of advanced glycation end products in the retinal microvasculature. LR-90 is an effective multistage inhibitor of advanced glycation with renoprotective and anti-inflammatory properties.
Aim
To explore the role of LR-90 in the progression of experimental diabetic retinopathy.
Methods
Streptozotocin-induced diabetic Sprague–Dawley rats were treated with LR-90 (50 mg/l in drinking water) for up to 32 weeks. At the end of the study, eyes were enucleated and subjected to trypsin digestion and staining with light green/haematoxylin. Acellular capillaries and pericytes were quantified in random fields using light microscopy.
Results
In the LR-90-treated diabetic animals, acellular capillary numbers were reduced to 1.63 (0.20) from 2.58 (0.49) (p<0.05) in diabetic controls. LR-90 treatment also restored the pericyte deficit from 18.12 (0.98) in diabetic rats to 24.19 (0.76) (p<0.001).
Conclusion
These findings show that LR-90 can effectively inhibit important lesions of diabetic retinopathy. This agent has potential for preventing retinopathy in patients with diabetes.
bjo.bmj.com