Liver X receptors link lipid metabolism and inflammation

IG Schulman - FEBS letters, 2017 - Wiley Online Library
FEBS letters, 2017Wiley Online Library
The response of immune cells to pathogens is often associated with changes in the flux
through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to
be necessary for a robust immune response. The Liver X receptors (LXR s) are members of
the nuclear hormone receptor superfamily that regulate gene networks controlling
cholesterol and lipid metabolism. In immune cells, particularly in macrophages, LXR s also
inhibit proinflammatory gene expression. This Review will highlight recent studies that …
The response of immune cells to pathogens is often associated with changes in the flux through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to be necessary for a robust immune response. The Liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that regulate gene networks controlling cholesterol and lipid metabolism. In immune cells, particularly in macrophages, LXRs also inhibit proinflammatory gene expression. This Review will highlight recent studies that connect LXR‐dependent control of lipid metabolism to regulation of the immune response.
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