[HTML][HTML] Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management
S McPherson, T Hardy, E Henderson, AD Burt… - Journal of …, 2015 - Elsevier
Background and Aims There remains uncertainty about the natural history of non-alcoholic
fatty liver disease (NAFLD). The spectrum of NAFLD includes non-alcoholic fatty liver (NAFL;
steatosis without hepatocellular injury) and steatohepatitis (NASH; steatosis with hepatocyte
ballooning degeneration±fibrosis). Our aim was to assess the histological severity of NAFLD
in a cohort with serial biopsy data, and determine factors predicting progression. Methods
Patients with two liver biopsies more than a year apart were identified. Clinical and …
fatty liver disease (NAFLD). The spectrum of NAFLD includes non-alcoholic fatty liver (NAFL;
steatosis without hepatocellular injury) and steatohepatitis (NASH; steatosis with hepatocyte
ballooning degeneration±fibrosis). Our aim was to assess the histological severity of NAFLD
in a cohort with serial biopsy data, and determine factors predicting progression. Methods
Patients with two liver biopsies more than a year apart were identified. Clinical and …