[HTML][HTML] α1-Fetoprotein transcription factor is required for the expression of sterol 12α-hydroxylase, the specific enzyme for cholic acid synthesis: potential role in the …
A del Castillo-Olivares, G Gil - Journal of Biological Chemistry, 2000 - ASBMB
Cholesterol conversion to bile acids occurs via the" classic"(neutral) or the"
alternative"(acidic) bile acid biosynthesis pathways. Sterol 12α-hydroxylase/CYP8b1 is the
specific enzyme required for cholic acid synthesis. The levels of this enzyme determine the
ratio of cholic acid to chenodeoxycholic acid and thus the hydrophobicity of the circulating
bile acid pool. Expression of the 12α-hydroxylase gene is tightly down-regulated by
hydrophobic bile acids. In this study, we report the characterization of two DNA elements that …
alternative"(acidic) bile acid biosynthesis pathways. Sterol 12α-hydroxylase/CYP8b1 is the
specific enzyme required for cholic acid synthesis. The levels of this enzyme determine the
ratio of cholic acid to chenodeoxycholic acid and thus the hydrophobicity of the circulating
bile acid pool. Expression of the 12α-hydroxylase gene is tightly down-regulated by
hydrophobic bile acids. In this study, we report the characterization of two DNA elements that …