The role of mitochondria in HIV infection and its treatment

M Pinti, M Nasi, L Gibellini, E Roat, S De Biasi… - Journal of Experimental …, 2010 - Elsevier
Mitochondria play a dual role in the life of the cell, being capable of producing either energy
(in the form of ATP) or potentially dangerous reactive oxygen species (ROS), and they also
contain molecules that, when released into the cytoplasm, cause apoptosis. There is a
growing interest in the importance of these organelles during the infection caused by the
human immunodeficiency virus (HIV), as well as during its treatment. Indeed, several drugs
that are capable of blocking HIV can also interact with the enzyme responsible for the …