The inimitable kynurenic acid: the roles of different ionotropic receptors in the action of kynurenic acid at a spinal level
G Tuboly, L Tar, Z Bohar, A Safrany-Fark… - Brain research …, 2015 - Elsevier
Kynurenic acid (KYNA) is a neuroactive metabolite that interacts with NMDA, AMPA/kainate
and alpha 7 nicotinic receptors. The goal of this study was to clarify the roles of these
receptors in the action of KYNA at a spinal level by using highly specific receptor antagonists
alone or in triple combinations. Chronic osteoarthritis-like joint pain was induced with
monosodium-iodoacetate in male Wistar rats. Mechanical allodynia and motor function were
quantified. In the first series we determined the dose–response and time course effects of …
and alpha 7 nicotinic receptors. The goal of this study was to clarify the roles of these
receptors in the action of KYNA at a spinal level by using highly specific receptor antagonists
alone or in triple combinations. Chronic osteoarthritis-like joint pain was induced with
monosodium-iodoacetate in male Wistar rats. Mechanical allodynia and motor function were
quantified. In the first series we determined the dose–response and time course effects of …