Immune effector mechanisms in malaria

MF Good, DL Doolan - Current opinion in immunology, 1999 - Elsevier
Current opinion in immunology, 1999Elsevier
Malaria, a disease responsible for immense human suffering, is caused by infection with
Plasmodium spp. parasites, which have a very complex life cycle ntigenically unique stages
infect different tissues of the body. This review details recent developments in our
understanding of immunity both to preerythrocytic stage antigens and to erythrocytic stage
antigens. The former is largely mediated via CD8+ T cells and involves IFN-γ, nitric oxide, IL-
12 and natural killer cells; the latter varies (in different hosts and with different parasites) but …
Malaria, a disease responsible for immense human suffering, is caused by infection with Plasmodium spp. parasites, which have a very complex life cycle ntigenically unique stages infect different tissues of the body. This review details recent developments in our understanding of immunity both to preerythrocytic stage antigens and to erythrocytic stage antigens. The former is largely mediated via CD8+ T cells and involves IFN-γ, nitric oxide, IL-12 and natural killer cells; the latter varies (in different hosts and with different parasites) but is largely mediated by antibody, helper T cells, nitric oxide and γδ T cells. The recent progress towards clinical trials of vaccine candidates against both the pre-erythrocytic stage and erythrocytic stage is also summarized, in particular the use of heterologous prime/boost strategies for the former and the use of MSP1 as a candidate vaccine for the latter.
Elsevier