Association of elevated plasma interleukin-18 level with increased mortality in a clinical trial of statin treatment for acute respiratory distress syndrome
AJ Rogers, J Guan, A Trtchounian… - Critical care …, 2019 - journals.lww.com
Objective: A high plasma level of inflammasome mediator interleukin-18 was associated
with mortality in observational acute respiratory distress syndrome cohorts. Statin exposure
increases both inflammasome activation and lung injury in mouse models. We tested
whether randomization to statin therapy correlated with increased interleukin-18 in the
ARDS Network Statins for Acutely Injured Lungs from Sepsis trial. Design: Retrospective
analysis of randomized controlled clinical trial. Setting: Multicenter North American clinical …
with mortality in observational acute respiratory distress syndrome cohorts. Statin exposure
increases both inflammasome activation and lung injury in mouse models. We tested
whether randomization to statin therapy correlated with increased interleukin-18 in the
ARDS Network Statins for Acutely Injured Lungs from Sepsis trial. Design: Retrospective
analysis of randomized controlled clinical trial. Setting: Multicenter North American clinical …