Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis
H He, H Suryawanshi, P Morozov… - Journal of Allergy and …, 2020 - Elsevier
Background Atopic dermatitis (AD) is a prevalent inflammatory skin disease with a complex
pathogenesis involving immune cell and epidermal abnormalities. Despite whole tissue
biopsy studies that have advanced the mechanistic understanding of AD, single cell–based
molecular alterations are largely unknown. Objective Our aims were to construct a detailed,
high-resolution atlas of cell populations and assess variability in cell composition and cell-
specific gene expression in the skin of patients with AD versus in controls. Methods We …
pathogenesis involving immune cell and epidermal abnormalities. Despite whole tissue
biopsy studies that have advanced the mechanistic understanding of AD, single cell–based
molecular alterations are largely unknown. Objective Our aims were to construct a detailed,
high-resolution atlas of cell populations and assess variability in cell composition and cell-
specific gene expression in the skin of patients with AD versus in controls. Methods We …