T cell subpopulaions in alopecia areata
N Todes-Taylor, R Turner, GS Wood, PT Stratte… - Journal of the American …, 1984 - Elsevier
Alopecia areata remains a disease of unknown cause and unsatisfactory treatment.
Histologically it is characterized by a lymphocytic infiltrate that surrounds the lower half of the
hair follicle. Our findings show that 64% to 92% of this infiltrate is composed of T
lymphocytes bearing the Leu 3a (helper-inducer) phenotype. The remaining lymphocytes
demonstrate the Leu 2a (cytotoxic-suppressor) phenotype. This helper T cell predominance
is present in all patients, irrespective of clinical activity or duration of disease. The Leu …
Histologically it is characterized by a lymphocytic infiltrate that surrounds the lower half of the
hair follicle. Our findings show that 64% to 92% of this infiltrate is composed of T
lymphocytes bearing the Leu 3a (helper-inducer) phenotype. The remaining lymphocytes
demonstrate the Leu 2a (cytotoxic-suppressor) phenotype. This helper T cell predominance
is present in all patients, irrespective of clinical activity or duration of disease. The Leu …