It has been suggested that a reduced number of nephrons may predispose to systemic
hypertension and glomerular injury. Compensatory hemodynamic changes, due to a low
number of glomeruli, might be responsible for glomerular functional and structural changes.
It is difficult to evaluate this hypothesis in humans because of limitations in estimating the
number of nephrons in the living kidney. The aim of the present study was to estimate
nephron number, single glomerular hemodynamics, and glomerular volume in male and …