Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space
CR Neal, H Crook, E Bell, SJ Harper… - Journal of the American …, 2005 - journals.lww.com
For more than 150 years, the only urinary space that has been recognized in the glomerulus
conducting primary filtrate to the proximal convoluted tubule has been Bowman's space
(BS)(1). Here it is shown that ultrastructural reconstructions of the podocyte and the
glomerulus reveal BS to be formed from three distinct urinary spaces through which filtrate
must pass before reaching the proximal convoluted tubule. The most restricted region, the
subpodocyte space (SPS; first described by Gautier in 1950), was found to cover 58 to 65 …
conducting primary filtrate to the proximal convoluted tubule has been Bowman's space
(BS)(1). Here it is shown that ultrastructural reconstructions of the podocyte and the
glomerulus reveal BS to be formed from three distinct urinary spaces through which filtrate
must pass before reaching the proximal convoluted tubule. The most restricted region, the
subpodocyte space (SPS; first described by Gautier in 1950), was found to cover 58 to 65 …