[HTML][HTML] AMP-activated protein kinase–mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase …

A Nakanishi, N Hatano, Y Fujiwara, A Sha'ri… - Journal of Biological …, 2017 - ASBMB
The Ca 2+/calmodulin-dependent protein kinase kinase β (CaMKKβ)/5′-AMP–activated
protein kinase (AMPK) phosphorylation cascade affects various Ca 2+-dependent metabolic
pathways and cancer growth. Unlike recombinant CaMKKβ that exhibits higher basal activity
(autonomous activity), activation of the CaMKKβ/AMPK signaling pathway requires
increased intracellular Ca 2+ concentrations. Moreover, the Ca 2+/CaM dependence of
CaMKKβ appears to arise from multiple phosphorylation events, including …