Aggrecanase-mediated cartilage degradation
EC Arner - Current opinion in pharmacology, 2002 - Elsevier
Increasing evidence is accumulating for the importance of the aggrecanases ADAMTS-4
and ADAMTS-5 in cartilage degradation in arthritis. Recent work from a number of
laboratories has begun to provide insight into the regulation of the expression and activity of
these proteins and the molecular basis of their role in aggrecan catabolism. Recombinant
ADAMTS-4 and ADAMTS-5 cleave aggrecan at five distinct sites along the core protein and
aggrecan fragments generated by cleavage at all of these sites have been identified in …
and ADAMTS-5 in cartilage degradation in arthritis. Recent work from a number of
laboratories has begun to provide insight into the regulation of the expression and activity of
these proteins and the molecular basis of their role in aggrecan catabolism. Recombinant
ADAMTS-4 and ADAMTS-5 cleave aggrecan at five distinct sites along the core protein and
aggrecan fragments generated by cleavage at all of these sites have been identified in …