Nitric oxide synthase and structure-based inhibitor design
TL Poulos, H Li - Nitric Oxide, 2017 - Elsevier
Once it was discovered that the enzyme nitric oxide synthase (NOS) is responsible for the
biosynthesis of NO, NOS became a drug target. Particularly important is the over production
of NO by neuronal NOS (nNOS) in various neurodegenerative disorders. After the various
NOS isoforms were identified, inhibitor development proceeded rapidly. It soon became
evident, however, that isoform selectivity presents a major challenge. All 3 human NOS
isoforms, nNOS, eNOS (endothelial NOS), and iNOS (inducible NOS) have nearly identical …
biosynthesis of NO, NOS became a drug target. Particularly important is the over production
of NO by neuronal NOS (nNOS) in various neurodegenerative disorders. After the various
NOS isoforms were identified, inhibitor development proceeded rapidly. It soon became
evident, however, that isoform selectivity presents a major challenge. All 3 human NOS
isoforms, nNOS, eNOS (endothelial NOS), and iNOS (inducible NOS) have nearly identical …