Hypertension is the largest preventable contributor to worldwide morbidity and mortality, and
improved understanding of hypertension pathophysiology could lead to major therapeutic
advances with major societal benefits. 1 Blood pressure is defined by the pressure of
circulating blood on the vessel wall, determined by the complex relationship between
cardiac output, vascular resistance, and vascular compliance. Hypertension can contribute
to or accelerate many cardiovascular diseases including kidney disease, or it may be a …